This project was intended to develop the investigative competencies of undergraduate Biological Science students. It has developed a problem-solving approach to designing student practicals in Immunology, changing the learning process from being teacher-focussed to learner-focussed and providing students through situated learning with the necessary skills to make decisions about what they do in the laboratory. A suite of problems created can be solved by the students' development of their own laboratory protocols, using learning support materials generated during the project The knowledge base consists of topic summaries, key references and detailed experimental protocols. A hypermedia version in HTML includes visuals of experimental outcomes and an image and audio glossary linked to the theory and experiments. The computer-based material produced in 1995 enhanced the use of paper resources on which the system was trialled in 1994 and broadened the scope and potential outcomes of the project to include use of the resources of the World Wide Web.